On the diabetic menu: Zebrafish as a model for pancreas development and function
- 9 February 2009
- Vol. 31 (2), 139-152
- https://doi.org/10.1002/bies.200800123
Abstract
Development of the vertebrate pancreas is a complex stepwise process comprising regionalization, cell differentiation, and morphogenesis. Studies in zebrafish are contributing to an emerging picture of pancreas development in which extrinsic signaling molecules influence intrinsic transcriptional programs to allow ultimate differentiation of specific pancreatic cell types. Zebrafish experiments have revealed roles for several signaling molecules in aspects of this process; for example our own work has shown that retinoic acid signals specify the pre‐pancreatic endoderm. Time‐lapse imaging of live zebrafish embryos has started to provide detailed information about early pancreas morphogenesis. In addition to modeling embryonic development, the zebrafish has recently been used as a model for pancreas regeneration studies. Here, we review the significant progress in these areas and consider the future potential of zebrafish as a diabetes research model.Keywords
This publication has 117 references indexed in Scilit:
- Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreasGenes & Development, 2008
- Intra-Endodermal Interactions Are Required for Pancreatic β Cell InductionDevelopmental Cell, 2008
- Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110Proceedings of the National Academy of Sciences of the United States of America, 2007
- Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductaseMechanisms of Development, 2007
- A genome-wide association study identifies novel risk loci for type 2 diabetesNature, 2007
- Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptorsDevelopmental Dynamics, 2006
- TALE-Family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endodermDevelopmental Biology, 2006
- Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cellsNature Biotechnology, 2006
- A conserved role for retinoid signaling in vertebrate pancreas developmentWilhelm Roux' Archiv für Entwicklungsmechanik der Organismen, 2004
- Pancreatic organogenesis — developmental mechanisms and implications for therapyNature Reviews Genetics, 2002