Proton Pump Inhibitors and Risk for Recurrent Clostridium difficile Infection

Abstract

Proton pump inhibitors (PPIs) are among the most commonly prescribed agents in outpatient and inpatient settings, but they are often used without a clear indication.^1,2 Although PPIs have been considered relatively safe, studies have demonstrated that PPI use and the use of other gastric acid suppressants are associated with a variety of infections, including Salmonella and Campylobacter gastroenteritis and community-acquired and nosocomial pneumonia.^3-7