Pediatric Nonalcoholic Fatty Liver Disease
- 1 March 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Gastroenterology Nursing
- Vol. 31 (2), 115-119
- https://doi.org/10.1097/01.sga.0000316530.31366.6e
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease related to excessive accumulation of hepatic fat, and represents a spectrum of liver disease ranging from fat accumulation alone (steatosis) to the more significant histologic finding of steatohepatitis. Nonalcoholic steatohepatitis is a progressive liver disease associated with increased risk of liver cirrhosis and cancer. NAFLD is becoming increasingly prevalent in the pediatric population in direct correlation with the emergence of childhood obesity as a significant pediatric health problem. The exact pathophysiology of NAFLD remains unclear, although the interplay of insulin resistance, oxidative stress, and release of proinflammatory cytokines are implicated in the process. The diagnostic workup and treatment for NAFLD and nonalcoholic steatohepatitis remains controversial. This review discusses current concepts regarding the natural history, pathophysiology, and management of pediatric patients with NAFLD.Keywords
This publication has 17 references indexed in Scilit:
- Non‐alcoholic fatty liver disease: Further expression of the metabolic syndromeJournal of Gastroenterology and Hepatology, 2007
- Prevalence of Fatty Liver in Children and AdolescentsPediatrics, 2006
- Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidationAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2006
- Nonalcoholic fatty liver disease and liver transplantationLiver Transplantation, 2006
- ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunitAmerican Journal of Physiology-Cell Physiology, 2006
- Evaluation and management of non-alcoholic steatohepatitisJournal of Hepatology, 2005
- A phase 2 clinical trial of metformin as a treatment for non‐diabetic paediatric non‐alcoholic steatohepatitisAlimentary Pharmacology & Therapeutics, 2005
- Trends in Risk Factors for Cardiovascular Disease Among Children and Adolescents in the United StatesPublished by American Academy of Pediatrics (AAP) ,2004
- Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot studyThe Journal of Pediatrics, 2000
- Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot studyHepatology, 1996