Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
Open Access
- 14 May 2012
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 209 (6), 1183-1199
- https://doi.org/10.1084/jem.20112667
Abstract
In the mouse lung, dendritic cells in the alveolar region but not the airway extend dendrites and take up antigen; antigen-loaded alveolar DCs then move to and accumulate in the airway where they encounter T cells.This publication has 56 references indexed in Scilit:
- CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigenThe Journal of Experimental Medicine, 2011
- Stabilized imaging of immune surveillance in the mouse lungNature Methods, 2010
- In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammationProceedings of the National Academy of Sciences of the United States of America, 2010
- Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergenThe Journal of Experimental Medicine, 2010
- Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenzaNature Immunology, 2010
- House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cellsNature Medicine, 2009
- Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigenJournal of Immunological Methods, 2008
- Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagementThe Journal of Experimental Medicine, 2006
- Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune systemThe Journal of Experimental Medicine, 2006
- Visualizing dendritic cell networks in vivoNature Immunology, 2004