Role of intra‐arterial hepatic chemotherapy in the treatment of colorectal cancer metastases
- 15 December 2010
- journal article
- review article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 102 (8), 988-995
- https://doi.org/10.1002/jso.21753
Abstract
Hepatic metastases are common with colorectal cancer. The primary blood supply to hepatic metastases is the hepatic artery. Regional chemotherapy utilizing the hepatic artery is one treatment option for liver metastases. The advantage of hepatic arterial chemotherapy is that high concentrations of the therapeutic drug are obtained in the liver with minimal systemic toxicity. Recently, systemic chemotherapy regimens have been added to hepatic arterial infusional chemotherapy to treat hepatic metastases. Due to the high response rates in the liver, resection rates are increasing in patients originally thought to have unresectable liver disease. Hepatic arterial chemotherapy has also been used in the adjuvant setting after resection of all liver metastases in order to minimize hepatic recurrences. The role of hepatic arterial infusional therapy in treating hepatic colorectal metastases includes treating patients with both resectable and unresectable metastases in the adjuvant, neoadjuvant, or palliative settings. J. Surg. Oncol. 2010;102:988–995.Keywords
This publication has 53 references indexed in Scilit:
- Conversion to Resectability Using Hepatic Artery Infusion Plus Systemic Chemotherapy for the Treatment of Unresectable Liver Metastases From Colorectal CarcinomaJournal of Clinical Oncology, 2009
- Phase II Trial of Cetuximab in Combination With Fluorouracil, Leucovorin, and Oxaliplatin in the First-Line Treatment of Metastatic Colorectal CancerJournal of Clinical Oncology, 2007
- Hepatic Arterial Infusion of Oxaliplatin and Intravenous LV5FU2 in Unresectable Liver Metastases from Colorectal Cancer after Systemic Chemotherapy FailureAnnals of Surgical Oncology, 2007
- Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastasesBritish Journal of Cancer, 2007
- Robotic-assisted placement of a hepatic artery infusion catheter for regional chemotherapySurgical Endoscopy, 2007
- Laparoscopic hepatic artery catheterization for regional chemotherapySurgical Endoscopy, 2006
- Laparoscopic Placement of Hepatic Artery Infusion Pumps: Technical Considerations and Early ResultsAnnals of Surgical Oncology, 2004
- Phase I/II Study of Hepatic Arterial Therapy With Floxuridine and Dexamethasone in Combination With Intravenous Irinotecan As Adjuvant Treatment After Resection of Hepatic Metastases From Colorectal CancerJournal of Clinical Oncology, 2003
- Repeat hepatectomy for colorectal liver metastases: A worthwhile operation?Journal of Surgical Oncology, 2001
- A reversible enteropathy complicating continuous hepatic artery infusion chemotherapy with 5-fluoro-2-deoxyuridineCancer, 1985