B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection
Open Access
- 25 October 2009
- journal article
- Published by Hindawi Limited in Interdisciplinary Perspectives on Infectious Diseases
- Vol. 2009, 1-6
- https://doi.org/10.1155/2009/864359
Abstract
Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB/cJ mice and IgD deficient BALB/c-Igh-mice to oral infection withPorphyromonas gingivalis, a gram-negative periodontopathic bacterium from humans.P. gingivalis-infected normal mice lost bone. Specific antibody toP. gingivaliswas lower and oral colonization was higher in IgD deficient mice; yet bone loss was completely absent. Infection increased the proportion of CDactivated B cells and CDT cells in immune normal mice compared to IgD deficient mice. These data suggest that IgD is an important mediator of alveolar bone resorption, possibly through antigen-specific coactivation of B cells and CDT cells.
Keywords
Funding Information
- United States Public Health Service (R01 DE10728, R01 DK56597)
This publication has 21 references indexed in Scilit:
- The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategiesJournal of Clinical Periodontology, 2007
- Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratioJournal of Clinical Periodontology, 2007
- B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal DiseaseThe American Journal of Pathology, 2006
- Effect of adoptive transfer of antigen‐specific B cells on periodontal bone resorptionJournal of Periodontal Research, 2006
- Immune Response: The Key to Bone Resorption in Periodontal DiseaseThe Journal of Periodontology, 2005
- T cell knockout mice have diminished alveolar bone loss after oral infection with Porphyromonas gingivalisFEMS Immunology & Medical Microbiology, 2002
- T cell knockout mice have diminished alveolar bone loss after oral infection withPorphyromonas gingivalisFEMS Immunology & Medical Microbiology, 2002
- Mixed Periodontal Th1-Th2 Cytokine Profile in Actinobacillus actinomycetemcomitans -Specific Osteoprotegerin Ligand (or RANK-L)- Mediated Alveolar Bone Destruction In VivoInfection and Immunity, 2002
- Genetic Control of Susceptibility toPorphyromonas gingivalis-Induced Alveolar Bone Loss in MiceInfection and Immunity, 2000
- Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.The Journal of Experimental Medicine, 1993