Comparison of the side effects and gastrointestinal motility observed after administration of erythromycin and josamycin to dogs
- 1 December 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 18 (6), 747-756
- https://doi.org/10.1093/jac/18.6.747
Abstract
The effects of intravenous erythromycin and josamycin on gastrointestinal motility in dogs have been compared. Erythromycin interrupted the basal motility pattern in the fasted state and induced irregular bursts of spikes in both the fasted and fed states. Emesis occurred in all the dogs in the fasted state experiments and in four out of six dogs in the fed state experiments. Josamycin did not disturb gastrointestinal motility and no dog showed signs of discomfort. The difference in the chemical structure of erythromycin and josamycin is the main reason for their differential effect on the gastrointestinal tract.Keywords
This publication has 5 references indexed in Scilit:
- Gastrointestinal side effects after intravenous erythromycin lactobionate.British Journal of Clinical Pharmacology, 1986
- Structure-activity relation among macrolide antibiotics in initiation of interdigestive migrating contractions in the canine gastrointestinal tractAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1985
- Erythromycin stearate, 1∣5 g, for the oral prophylaxis of streptococcal bacteraemia in patients undergoing dental extraction: efficacy and toleranceJournal of Antimicrobial Chemotherapy, 1985
- INHIBITION OF THE PENDULAR MOVEMENTS OF THE INTESTINE BY AMINOGLYCOSIDE ANTIBIOTICS1981
- ADVANCES IN ANTIBIOTIC THERAPYAnnals of Internal Medicine, 1953