COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice
- 10 December 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 306 (5703), 1954-1957
- https://doi.org/10.1126/science.1103333
Abstract
Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to up-regulate the production of atheroprotective prostacyclin, PGI 2 , by activation of cyclooxygenase 2 (COX-2). This mechanism restrained both oxidant stress and platelet activation that contribute to atherogenesis in female mice. Deletion of the PGI 2 receptor removed the atheroprotective effect of estrogen in ovariectomized female mice. This suggests that chronic treatment of patients with selective inhibitors of COX-2 could undermine protection from cardiovascular disease in premenopausal females.Keywords
This publication has 16 references indexed in Scilit:
- Backscatter from LeadNew England Journal of Medicine, 2004
- Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β LigandsJournal of Medicinal Chemistry, 2004
- Detection of Superoxide in Vascular TissueArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2Science, 2002
- Roles of Prostaglandin I 2 and Thromboxane A 2 in Cardiac Ischemia-Reperfusion InjuryCirculation, 2001
- Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient miceNature Medicine, 1998
- 17β-Estradiol Attenuates Acetylcholine-Induced Coronary Arterial Constriction in Women but Not Men With Coronary Heart DiseaseCirculation, 1995
- Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters. Octimibate and BMY 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor activity, and tumor necrosis factor production.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1993
- Sex, plasma lipoproteins, and atherosclerosis: Prevailing assumptions and outstanding questionsAmerican Heart Journal, 1987
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976