Methylsulphone metabolites ofm-dichlorobenzene as ligands fora2u-globulin in rat kidney and urine
- 1 January 1990
- journal article
- research article
- Published by Informa UK Limited in Xenobiotica
- Vol. 20 (1), 7-17
- https://doi.org/10.3109/00498259009046808
Abstract
1. Kidneys from rats given oral doses of either 3,5- or 2,4-dichlorophenyl[14C]methylsulphide contained the corresponding sulphones that were associated with a protein which has been isolated and characterized by SDS-polyacrylamide gel electrophoresis and immunoblot analysis to be a2u-globulin. 2. The same methylsulphone-a2u-globulin complex was isolated from the urine from rats doses with 3,5-dichlorophenyl[14C]methylsulphide (0.3–1.0% of dose, 8.5% of 14C in urine). 3. The stoichiometry of binding of the isolated methylsulphone-a2u-globulin complex was shown to be 0.54—0.78 nmol/nmol protein. This binding was not covalent.This publication has 20 references indexed in Scilit:
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