Cefepime: a reappraisal in an era of increasing antimicrobial resistance
- 1 December 2008
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Anti-infective Therapy
- Vol. 6 (6), 805-824
- https://doi.org/10.1586/14787210.6.6.805
Abstract
Cefepime is a ‘fourth-generation’ cephalosporin with an in vitro extended-spectrum of activity against Gram-negative and Gram-positive pathogens. Cefepime is approved for the treatment of moderate-to-severe infections, such as pneumonia, uncomplicated and complicated urinary tract infections, skin and soft-tissue infections, intra-abdominal infections and febrile neutropenia. In this article, we provide a critical review of pharmacodynamics, clinical management, pharmacokinetics, metabolism, pharmacodynamic target analyses, clinical efficacy, safety and tolerability of cefepime after more than a decade of clinical use.Keywords
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