Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol
Open Access
- 8 May 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 427 (2), 283-285
- https://doi.org/10.1016/s0014-5793(98)00450-5
Abstract
A new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (GOT), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of Cannabis sativa. The enz...Keywords
This publication has 15 references indexed in Scilit:
- Enzymological Evidence for Cannabichromenic Acid BiosynthesisJournal of Natural Products, 1997
- Dimethylallyl diphosphate: Kaempferol 8-dimethylallyl transferase in Epimedium diphyllum cell suspension culturesPhytochemistry, 1997
- Prenylierung von Benzoesäurederivaten, katalysiert durch eine Transferase ausEscherichia-coli-Überproduzenten: Verfahrensentwicklung und SubstratspezifitätAngewandte Chemie, 1996
- Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L.Journal of Biological Chemistry, 1996
- Biosynthesis of primin and miconidin and its derivativesPhytochemistry, 1996
- First direct evidence for the mechanism of .DELTA.1-tetrahydrocannabinolic acid biosynthesisJournal of the American Chemical Society, 1995
- Cannabinerolic acid, a cannabinoid from Cannabis sativaPhytochemistry, 1995
- Intracellular localization of p-hydroxybenzoate geranyltransferase, a key enzyme involved in shikonin biosynthesisPhytochemistry, 1993
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Tetrahydrocannabinolic Acid, a Genuine Substance of TetrahydrocannabinolCHEMICAL & PHARMACEUTICAL BULLETIN, 1967