Fungal and Parasitic Infections of the Eye
Open Access
- 1 October 2000
- journal article
- review article
- Published by American Society for Microbiology in Clinical Microbiology Reviews
- Vol. 13 (4), 662-685
- https://doi.org/10.1128/cmr.13.4.662-685.2000
Abstract
The unique structure of the human eye as well as exposure of the eye directly to the environment renders it vulnerable to a number of uncommon infectious diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insufficient to prevent loss of vision. Therefore, the timely identification and treatment of the involved microorganisms are paramount. The anatomy of the eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to penetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. Fungal endophthalmitis and chorioretinitis, on the other hand, are usually the result of antecedent fungemia seeding the ocular tissue. Candida spp. are the most common cause of endogenous endophthalmitis, although initial infection with the dimorphic fungi may lead to infection and scarring of the chorioretina. Contact lens wear is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.Keywords
This publication has 98 references indexed in Scilit:
- Paecilomycosis of the lacrimal sacMycoses, 2009
- Fungal Adherence to the Vascular Compartment: A Critical Step in the Pathogenesis of Disseminated CandidiasisClinical Infectious Diseases, 1992
- Use of lactophenol cotton blue mounts of corneal scrapings as an aid to the diagnosis of mycotic keratitisDiagnostic Microbiology and Infectious Disease, 1991
- Contact lens surface deposits increase the adhesion of Pseudomonas aeruginosaCurrent Eye Research, 1990
- The Anophthalmic Socket and the Prosthetic Eye A Clinical and Bacteriologic StudyOphthalmic Plastic & Reconstructive Surgery, 1989
- Toxoplasmosis: the Time Has ComeThe New England Journal of Medicine, 1988
- THE PATHOGENESIS OF ENDOPHTHALMITISInternational Ophthalmology Clinics, 1987
- Intestinal Giardiasis Associated with Ocular InflammationJournal of Clinical Gastroenterology, 1985
- Toxocaral Visceral Larva MigransThe New England Journal of Medicine, 1978
- Fungal flora of the normal conjunctival sacMycoses, 1977