Prevention of Urethane - Induced Lung Adenomas byWithania somnifera(L.) Dunal in Albino Mice
- 1 January 1986
- journal article
- research article
- Published by Informa UK Limited in International Journal of Crude Drug Research
- Vol. 24 (2), 90-100
- https://doi.org/10.3109/13880208609083312
Abstract
Withania somnifera (L.) Dunal was evaluated for its tumor-preventing activity against urethane-induced lung adenomas in adult male albino mice. Administration of urethane in a dose of 125 mg/kg given subcutaneously biweekly for 7 months induced lung adenomas in 100% of animals. Urethane was also found to cause significant decrease in body weight, increase in mortality, leucopaenia and decrease in lymphocyte percentage as compared to untreated controls. Simultaneous oral administration of W. somnifera given in a dose of 200 mg/kg daily along with urethane protected the animals from the tumor-inducing effect of urethane. It also prevented the decrease in body weight and increase in mortality caused by urethane. The haematological changes were found to be completely reversed as evidenced by significant increases in total leucocyte count and lymphocyte percentage. These haematological changes were also observed in the animals treated with W. somnifera alone. It appears that W. somnifera may be preventing urethane-induced lung adenomas by inducing a state of nonspecific increase in resistance (adaptogen) and immunostimulant properties.Keywords
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