Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies
- 15 September 2019
- journal article
- research article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 178, 500-514
- https://doi.org/10.1016/j.ejmech.2019.05.087
Abstract
No abstract availableKeywords
Funding Information
- EPSRC
- Royal Society (RG160870)
- University of London
- University of Rome “La Sapienza”
This publication has 51 references indexed in Scilit:
- Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacyBioorganic & Medicinal Chemistry Letters, 2011
- Race against time to develop new antibioticsBulletin of the World Health Organization, 2011
- Empirical Scoring Functions for Advanced Protein−Ligand Docking with PLANTSJournal of Chemical Information and Modeling, 2009
- Outer membrane permeability and antibiotic resistanceBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2008
- Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity RelationshipsJournal of Medicinal Chemistry, 2008
- Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase InhibitorsAntimicrobial Agents and Chemotherapy, 2008
- Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2006
- In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitorsBioorganic & Medicinal Chemistry Letters, 2005
- A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic Topoisomerase IIAntimicrobial Agents and Chemotherapy, 2004
- The worldwide prevalence of methicillin-resistant Staphylococcus aureusInternational Journal of Antimicrobial Agents, 1995