Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection
Open Access
- 28 September 2020
- journal article
- research article
- Published by SAGE Publications in Journal of Human Lactation
- Vol. 36 (4), 609-613
- https://doi.org/10.1177/0890334420960433
Abstract
Human milk cannot currently be considered a major source of COVID-19 infection. On the other hand, it can contain specific antibodies that could modulate a possible newborn infection by SARS-CoV-2. A 32-year-old pregnant woman, gestational age 37 and 3/7 weeks, was admitted with a flu-like syndrome caused by COVID-19. The female newborn was appropriate for gestational age, with a birth weight of 2,890 g, length 48 cm, and head circumference 34 cm. The mother–infant dyad remained in the rooming-in unit during hospitalization, exclusively breastfeeding and following World Health Organization recommendations for contact and airway precautions. On the 3rd day after delivery, two mother’s milk samples (3 and 5 mL) were collected by hand expression. The samples were centrifuged for 10 min twice consecutively to separate fat, which was removed, and the remaining material was transferred to another tube to determine anti-SARS-CoV-2 Immunoglobulin A and Immunoglobulin G (ELISA, Kit EUROIMMUN AG, Luebeck, Germany). Anti-SARS-CoV-2 Immunoglobulin A was detected in the two samples evaluated, whose values were 2.5 and 1.9, respectively. No anti-SARSCoV-2 immunoglobulin G was detected. The exclusively-breastfed infant remained well through 45 days of age. The presence of SARS-CoV-2 Immunoglobulin A in the milk of mothers infected with COVID-19 may be related to protection against the transmission and severity of the disease in their infants.Keywords
This publication has 11 references indexed in Scilit:
- Protecting Breastfeeding during the COVID-19 PandemicAmerican Journal of Perinatology, 2020
- SARS‐CoV‐2 and human milk: What is the evidence?Maternal & Child Nutrition, 2020
- Breast feeding at the time of COVID-19: do not forget expressed mother’s milk, pleaseArchives of Disease in Childhood: Fetal & Neonatal, 2020
- Detection of SARS-CoV-2 in Different Types of Clinical SpecimensJAMA, 2020
- A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing EnterocolitisNutrients, 2019
- Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effectThe Lancet, 2016
- Breastfeeding after maternal immunisation during pregnancy: Providing immunological protection to the newborn: A reviewVaccine, 2014
- IgA and Neutralizing Antibodies to Influenza A Virus in Human Milk: A Randomized Trial of Antenatal Influenza ImmunizationPLOS ONE, 2013
- The Mucosal Immune System and Its Integration with the Mammary GlandsThe Journal of Pediatrics, 2010
- Transfer of antibody via mother's milk.Vaccine, 2003