Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
Open Access
- 20 July 2012
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 123 (1), 14-20
- https://doi.org/10.1111/j.1471-4159.2012.07883.x
Abstract
White matter impairment is a feature of vascular depression. The anti‐psychotic quetiapine has been shown to enhance the therapeutic effects of anti‐depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo‐treated mice on post‐operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti‐depressant effects through white matter protection in vascular depression.Keywords
This publication has 21 references indexed in Scilit:
- Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: Possible involvement of nitric oxide-cyclic guanosine monophosphate study pathwayBrain Research Bulletin, 2010
- Hyperoxic Reperfusion after Global Cerebral Ischemia Promotes Inflammation and Long-Term Hippocampal Neuronal DeathJournal of Neurotrauma, 2010
- The life, death, and replacement of oligodendrocytes in the adult CNSJournal of Neurochemistry, 2008
- Microstructural White Matter Abnormalities and Remission of Geriatric DepressionAmerican Journal of Psychiatry, 2008
- White matter hyperintensities in late life depression: a systematic reviewJournal of Neurology, Neurosurgery & Psychiatry, 2007
- The cognitive neuropsychology of depression in the elderlyPsychological Medicine, 2007
- Add-on quetiapine in the treatment of major depressive disorder in elderly patients with cerebrovascular damageClinical Practice and Epidemiology in Mental Health, 2007
- Minocycline alleviates hypoxic–ischemic injury to developing oligodendrocytes in the neonatal rat brainNeuroscience, 2005
- Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathyPharmacology Biochemistry and Behavior, 2005
- Selective Neuronal Vulnerability and Specific Glial Reactions in Hippocampal and Neocortical Organotypic Cultures Submitted to IschemiaExperimental Neurology, 1998