Dementia and Alzheimer Disease Incidence Rates Do Not Vary by Sex in Rochester, Minn

Abstract
WHILE CAUSAL genetic mutations, susceptibility genes, and environmental risk factors for Alzheimer disease (AD) have been identified, these factors collectively account for one half or less of all cases, and additional risk factors will likely be identified.1 In some studies, women have an increased incidence of AD compared with men, and it has been hypothesized that being female is a risk factor for AD.2 Recent reports that estrogen replacement therapy may improve memory performance and protect against AD suggest a biological basis for an increased risk of AD in postmenopausal women.3-5