Safe and effective application of anti-TNF- in a patient infected with HIV and concomitant Crohn's disease

Abstract
CD causes an increase in tumour necrosis factor α (TNF-α) that seems to play a fundamental role in the condition. Thus anti-TNF-α therapies represent a step forward in the management of CD.4 Elevated TNF-α levels are also observed during all stages of HIV, and consequently the use of anti-TNF-α agents has been also suggested for HIV patients.5 To date, three controlled trials of anti-TNF-α based therapies6– , 8 in HIV patients have been reported. Each study registered …