Short-Term Thermal-Humidity Shock Affects Point-of-Care Glucose Testing
Open Access
- 1 January 2014
- journal article
- research article
- Published by SAGE Publications in Journal of Diabetes Science and Technology
- Vol. 8 (1), 83-88
- https://doi.org/10.1177/1932296813514325
Abstract
Objective: The objective was to assess the effects of short-term (≤1 hour) static high temperature and humidity stresses on the performance of point-of-care (POC) glucose test strips and meters. Background: Glucose meters are used by medical responders and patients in a variety of settings including hospitals, clinics, homes, and the field. Reagent test strips and instruments are potentially exposed to austere environmental conditions. Methods: Glucose test strips and meters were exposed to a mean relative humidity of 83.0% (SD = 8.0%) and temperature of 42°C (107.6°F, SD = 3.2) in a Tenney BTRC environmental chamber. Stressed and unstressed glucose reagent strips and meters were tested with spiked blood samples (n = 40 measurements per time point for each of 4 trials) after 15, 30, 45, and 60 minutes of exposure. Wilcoxon’s signed rank test was applied to compare measurements test strip and meter measurements to isolate and characterize the magnitude of meter versus test strip effects individually. Results: Stressed POC meters and test strips produced elevated glucose results, with stressed meter bias as high as 20 mg/dL (17.7% error), and stressed test strip bias as high as 13 mg/dL (12.2% error). The aggregate stress effect on meter and test strips yielded a positive bias as high as 33 mg/dL (30.1% error) after 15 minutes of exposure. Conclusions: Short-term exposure (15 minutes) to high temperature and humidity can significantly affect the performance of POC glucose test strips and meters, with measurement biases that potentially affect clinical decision making and patient safety.Keywords
This publication has 14 references indexed in Scilit:
- Effects of Dynamic Temperature and Humidity Stresses on Point-of-Care Glucose Testing for Disaster CareDisaster Medicine and Public Health Preparedness, 2012
- A Thermo-Modulating Container for Transport and Storage of Glucose Meters in a Cold Weather EnvironmentPoint of Care: The Journal of Near-Patient Testing & Technology, 2012
- Thermal Stress and Point-of-Care Testing Performance: Suitability of Glucose Test Strips and Blood Gas Cartridges for Disaster ResponseDisaster Medicine and Public Health Preparedness, 2009
- Mass Medical Evacuation: Hurricane Katrina and Nursing Experiences at the New Orleans AirportDisaster Management & Response, 2007
- Inside and somewhat outside CharityJournal of Neurosurgery, 2007
- Katrina, the Tsunami, and Point-of-Care TestingAmerican Journal of Clinical Pathology, 2006
- Irreversible Thermal Denaturation of Glucose Oxidase from Aspergillus niger Is the Transition to the Denatured State with Residual StructureJournal of Biological Chemistry, 2004
- Thermal Inactivation of Glucose OxidaseJournal of Biological Chemistry, 2003
- The relationship between the glucose oxidase subunit structure and its thermostabilityBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
- Thermal stability of glucose oxidase and its admixtures with synthetic polymersBiotechnology & Bioengineering, 1973