Label-free Biosensing Based on Single Gold Nanostars as Plasmonic Transducers
- 13 October 2010
- journal article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 4 (11), 6318-6322
- https://doi.org/10.1021/nn100760f
Abstract
Gold nanostars provide high sensitivity for single nanoparticle label-free biosensing. The nanostars present multiple plasmon resonances of which the lower energy ones, corresponding to the nanostar tips and core-tip interactions, are the most sensitive to environmental changes. Streptavidin molecules are detected upon binding to individual, biotin-modified gold nanostars by spectral shifts in the plasmon resonances. Concentrations as low as 0.1 nM produce a shift of the tip related plasmon resonances of about 2.3 nm (5.3 meV).Keywords
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