Thoughts and facts about antibiotics: Where we are now and where we are heading
Top Cited Papers
- 18 April 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in The Journal of Antibiotics
- Vol. 65 (8), 385-395
- https://doi.org/10.1038/ja.2012.27
Abstract
The declining trends in microbial metabolite and natural products research and the refocusing of this research area are discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing natural products over synthetic compounds are emphasized.Keywords
This publication has 47 references indexed in Scilit:
- Bacterial symbionts and natural productsChemical Communications, 2011
- Role of natural product diversity in chemical biologyCurrent Opinion in Chemical Biology, 2011
- Recent Advances in the Chemistry and Biology of Naturally Occurring AntibioticsAngewandte Chemie-International Edition, 2009
- Maternal regulation of estrogen receptor α methylationCurrent Opinion in Pharmacology, 2008
- Renaissance in antibacterial discovery from actinomycetesCurrent Opinion in Pharmacology, 2008
- Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineeringMetabolic Engineering, 2008
- Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblagesProceedings of the National Academy of Sciences of the United States of America, 2008
- Antibiotics as intermicrobial signaling agents instead of weaponsProceedings of the National Academy of Sciences of the United States of America, 2006
- The Impact of Bacterial Genomics on Natural Product ResearchAngewandte Chemie-International Edition, 2005
- Bioactive Microbial MetabolitesThe Journal of Antibiotics, 2005