Function ofPseudomonasPorins in Uptake and Efflux
- 1 October 2002
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 56 (1), 17-38
- https://doi.org/10.1146/annurev.micro.56.012302.160310
Abstract
▪ Abstract Porins are proteins that form water-filled channels across the outer membranes of Gram-negative bacteria and thus make this membrane semipermeable. There are four types of porins: general/nonspecific porins, substrate-specific porins, gated porins, and efflux porins (also called channel-tunnels). The recent publication of the genomic sequence of Pseudomonas aeruginosa PAO1 has dramatically increased our understanding of the porins of this organism. In particular this organism has 3 large families of porins: the OprD family of specific porins (19 members), the OprM family of efflux porins (18 members), and the TonB-interacting family of gated porins (35 members). These familial relationships underlie functional similarities such that well-studied members of these families become prototypes for other members. We summarize here the latest information on these porins.Keywords
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