Family History and the Risk of Kidney Cancer: a Multicenter Case-control Study in Central Europe
- 1 June 2007
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 16 (6), 1287-1290
- https://doi.org/10.1158/1055-9965.epi-06-0963
Abstract
An elevated familial relative risk may indicate either an important genetic component in etiology or shared environmental exposures within the family. Incidence rates of kidney cancer are particularly high in Central Europe, although no data were available on the familial aggregation or genetic background of kidney cancer in this region. We have, therefore, investigated the role of family history in first-degree relatives in a large multicenter case-control study in Central Europe. A total number of 1,097 cases of kidney cancer and 1,555 controls were recruited from 2000 to 2003 from seven centers in Czech Republic, Poland, Romania, and Russia. The risk of kidney cancer increased with the increasing number of relatives with history of any cancer [odds ratio (OR), 1.15; 95% confidence interval (95% CI), 1.00-1.31 per affected relative], and this association seemed to be more prominent among subjects with young onset (OR, 1.55; 95% CI, 1.09-2.20 per affected relative). Overall, the OR was 1.40 (95% CI, 0.71- 2.76) for the subjects who had at least one first-degree relative with kidney cancer after adjusting for tobacco smoking, body mass index, and medical history of hypertension, and this association was most apparent among subjects with affected siblings (OR, 4.09; 95% CI, 1.09-15.4). Based on the relative risk to siblings in our study population, we estimated that 80% of the kidney cancer cases are likely to occur in 20% of the population with the highest genetic risk, which indicate the importance of further investigation of genetic factors in cancer prevention for kidney cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1287–90)Keywords
This publication has 12 references indexed in Scilit:
- Family History of Cancer and the Risk of Renal Cell CancerCancer Epidemiology, Biomarkers & Prevention, 2006
- Genomics of renal cell cancer — Does it provide breakthrough?Pathology and Oncology Research, 2006
- Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear FamilyPLoS Medicine, 2004
- The genetic basis of renal cell carcinomaUrologic Clinics of North America, 2003
- A population‐based familial aggregation analysis indicates genetic contribution in a majority of renal cell carcinomasInternational Journal of Cancer, 2002
- Kidney cancer in the Swedish Family Cancer Database: Familial risks and second primary malignanciesKidney International, 2002
- Polygenic susceptibility to breast cancer and implications for preventionNature Genetics, 2002
- Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and FinlandNew England Journal of Medicine, 2000
- Hereditary and Sporadic Papillary Renal Carcinomas with c-met Mutations Share a Distinct Morphological PhenotypeThe American Journal of Pathology, 1999
- Risk factors for renal cell carcinoma: results of a population-based case-control studyCancer Causes and Control, 1993