Viral-bacterial co-infection in Australian Indigenous children with acute otitis media
Open Access
- 7 June 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 11 (1), 161
- https://doi.org/10.1186/1471-2334-11-161
Abstract
Acute otitis media with perforation (AOMwiP) affects 40% of remote Indigenous children during the first 18 months of life. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the primary bacterial pathogens of otitis media and their loads predict clinical ear state. Our hypothesis is that antecedent respiratory viral infection increases bacterial density and progression to perforation. A total of 366 nasopharyngeal swabs from 114 Indigenous children were retrospectively examined. A panel of 17 respiratory viruses was screened by PCR, and densities of S. pneumoniae, H. influenzae and M. catarrhalis were estimated by quantitative real time PCR. Data are reported by clinical ear state. M. catarrhalis (96%), H. influenzae (91%), S. pneumoniae (89%) and respiratory viruses (59%) were common; including rhinovirus (HRV) (38%), polyomavirus (HPyV) (14%), adenovirus (HAdV) (13%), bocavirus (HBoV) (8%) and coronavirus (HCoV) (4%). Geometric mean bacterial loads were significantly higher in children with acute otitis media (AOM) compared to children without evidence of otitis media. Children infected with HAdV were 3 times more likely (p < 0.001) to have AOM with or without perforation. This study confirms a positive association between nasopharyngeal bacterial load and clinical ear state, exacerbated by respiratory viruses, in Indigenous children. HAdV was independently associated with acute ear states.Keywords
This publication has 41 references indexed in Scilit:
- Joining the dots: The links between education and health and implications for Indigenous childrenJournal of Paediatrics and Child Health, 2009
- Pneumococcal vaccination and otitis media in Australian Aboriginal infants: comparison of two birth cohorts before and after introduction of vaccinationBMC Pediatrics, 2009
- Detection of human bocavirus in respiratory, fecal, and blood samples by real‐time PCRJournal of Medical Virology, 2009
- Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: A randomized controlled trialBMC Pediatrics, 2008
- Viral Upper Respiratory Tract Infection and Otitis Media Complication in Young ChildrenClinical Infectious Diseases, 2008
- Insights into the Interaction between Influenza Virus and PneumococcusClinical Microbiology Reviews, 2006
- Streptococcus pneumoniae and Noncapsular Haemophilus influenzae Nasal Carriage and Hand Contamination in ChildrenThe Pediatric Infectious Disease Journal, 2005
- Quantitative Detection of Moraxella catarrhalis in Nasopharyngeal Secretions by Real-Time PCRJournal of Clinical Microbiology, 2003
- Efficacy of Intranasal Virosomal Influenza Vaccine in the Prevention of Recurrent Acute Otitis Media in ChildrenClinical Infectious Diseases, 2002
- TEMPORAL DEVELOPMENT OF ACUTE OTITIS MEDIA DURING UPPER RESPIRATORY TRACT INFECTIONThe Pediatric Infectious Disease Journal, 1994