Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension
- 9 August 2011
- journal article
- Published by Springer Science and Business Media LLC in Medical Oncology
- Vol. 29 (3), 1638-1642
- https://doi.org/10.1007/s12032-011-0038-2
Abstract
Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination. In every patient, at least 1 but no more than 4 biopsies were taken from places visualized as pathologic, surrounding primary tumor, and at least 1 biopsy from places that appeared visually normal. Sensitivity, specificity, positive, and negative predictive value for autofluorescence imaging in the assessment of tumor extension were 89.2, 77.8, 87, and 81%, respectively. Sensitivity, specificity, positive, and negative predictive value for narrow band imaging were 90.4, 82.4, 91.8, and 79.7%, respectively. Corresponding values for combination of techniques were 93.7, 86.9, 94.5, and 85.1%. Combination of techniques significantly improves sensitivity (P = 0.034) with borderline effect on specificity (P = 0.056) of autofluorescence imaging. There was no significant improvement for sensitivity and specificity of NBI alone. The combination of techniques shows significantly better sensitivity and specificity in the assessment of lung cancer extension when compared to white light videobronchoscopy alone, but improvement is not so convincing when compared to the each technique alone.Keywords
This publication has 27 references indexed in Scilit:
- Playing with the wavelengths: Endoscopic early lung cancer detectionLung Cancer, 2010
- Early detection of lung cancerPublished by European Respiratory Society (ERS) ,2010
- Use of narrow-band imaging bronchoscopy in detection of lung cancerExpert Review of Medical Devices, 2010
- Interventional Bronchoscopy from Bench to Bedside: New Techniques for Early Lung Cancer DetectionClinics in Chest Medicine, 2010
- Early Diagnosis of Lung CancerClinics in Chest Medicine, 2010
- Narrow-Band Imaging Bronchoscopy Increases the Specificity of Bronchoscopic Early Lung Cancer DetectionJournal of Thoracic Oncology, 2009
- Early proximal lung cancer diagnosis and treatmentEuropean Respiratory Journal, 2009
- Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical TrialJournal of Thoracic Oncology, 2009
- Autofluorescence bronchoscopy: quantification of inter-patient variations of fluorescence intensityLasers in Medical Science, 2007
- Autofluorescence bronchoscopy with white light bronchoscopy compared with white light bronchoscopy alone for the detection of precancerous lesions: a European randomised controlled multicentre trialThorax, 2005