Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure
Top Cited Papers
- 2 November 2004
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 110 (18), 2864-2868
- https://doi.org/10.1161/01.cir.0000146336.92331.d1
Abstract
Background— The effects of cardiac resynchronization therapy (CRT) in patients with mildly symptomatic heart failure have not been fully elucidated. Methods and Results— The Multicenter InSync ICD Randomized Clinical Evaluation II (MIRACLE ICD II) was a randomized, double-blind, parallel-controlled clinical trial of CRT in NYHA class II heart failure patients on optimal medical therapy with a left ventricular (LV) ejection fraction ≤35%, a QRS ≥130 ms, and a class I indication for an ICD. One hundred eighty-six patients were randomized: 101 to the control group (ICD activated, CRT off) and 85 to the CRT group (ICD activated, CRT on). End points included peak V̇ o 2 , V̇ e /V̇ co 2 , NYHA class, quality of life, 6-minute walk distance, LV volumes and ejection fraction, and composite clinical response. Compared with the control group at 6 months, no significant improvement was noted in peak V̇ o 2 , yet there were significant improvements in ventricular remodeling indexes, specifically LV diastolic and systolic volumes ( P =0.04 and P =0.01, respectively), and LV ejection fraction ( P =0.02). CRT patients showed statistically significant improvement in V̇ e /V̇ co 2 ( P =0.01), NYHA class ( P =0.05), and clinical composite response ( P =0.01). No significant differences were noted in 6-minute walk distance or quality of life scores. Conclusions— In patients with mild heart failure symptoms on optimal medical therapy with a wide QRS complex and an ICD indication, CRT did not alter exercise capacity but did result in significant improvement in cardiac structure and function and composite clinical response over 6 months.Keywords
This publication has 13 references indexed in Scilit:
- Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart FailureNew England Journal of Medicine, 2004
- Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmiasJournal of the American College of Cardiology, 2003
- Combined Cardiac Resynchronization and Implantable Cardioversion Defibrillation in Advanced Chronic Heart FailureJAMA, 2003
- Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart FailureCirculation, 2003
- Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) studyJournal of the American College of Cardiology, 2002
- Cardiac Resynchronization in Chronic Heart FailureNew England Journal of Medicine, 2002
- Exercise performance following cardiac resynchronization therapy in patients with heart failure and ventricular conduction delayThe American Journal of Cardiology, 2002
- Biventricular pacing decreases the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathyThe American Journal of Cardiology, 2001
- Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction DelayNew England Journal of Medicine, 2001
- Biventricular pacing diminishes the need for implantable cardioverter defibrillator therapyJournal of the American College of Cardiology, 2000