Life quality assessment among patients with atopic eczema
- 6 December 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 154 (4), 719-725
- https://doi.org/10.1111/j.1365-2133.2005.07050.x
Abstract
Quantification of quality of life (QoL) related to disease severity is important in patients with atopic eczema (AE), because the assessment provides additional information to the traditional objective clinical scoring systems. To measure health-related QoL (HRQoL) in patients with AE; to analyse discriminant, divergent and convergent validity by examining the association between various QoL methods; and to examine the association between disease severity assessed by an objective Severity Scoring of Atopic Dermatitis (SCORAD) and QoL. HRQoL was assessed at two visits at a 6-monthly interval in 101 patients with AE and 30 controls with one dermatology-specific questionnaire [Dermatology Life Quality Index (DLQI) or Children's DLQI (CDLQI)], one generic instrument (SF-36) and three visual analogue scales (VASs) of severity and pruritus. Objective SCORAD was used to measure disease severity. Patients with AE had significantly lower QoL than healthy controls and the general population. DLQI /CDLQI, pruritus, and patient and investigator overall assessment of eczema severity were significantly (P < 0.0001) and positively correlated with SCORAD, while the generic questionnaire showed only poor correlation. A gender difference was found for the mental component score of SF-36 (P = 0.019). AE has an impact on HRQoL. Patients' mental health, social functioning and role emotional functioning seem to be more affected than physical functioning. A simple VAS score of patients' assessment of disease severity showed the highest and most significant correlations with most of the HRQoL methods used. There is evidence to support the ability of patients with AE to make an accurate determination of their disease severity and QoL.Keywords
This publication has 44 references indexed in Scilit:
- The Children's Dermatology Life Quality Index (CDLQI): initial validation and practical useBritish Journal of Dermatology, 2010
- Predicting Long-Term Outcome in Group Treatment of Atopic DermatitisPsychotherapy and Psychosomatics, 2004
- Long-Term Efficacy and Safety of Pimecrolimus Cream 1% in Adults with Moderate Atopic DermatitisDermatology, 2004
- Quality of life and disease severity are correlated in children with atopic dermatitisBritish Journal of Dermatology, 2004
- Disease severity and associated family impact in childhood atopic dermatitisArchives of Disease in Childhood, 2003
- Patient-Reported Outcomes: The Example of Health-Related Quality of Life—a European Guidance Document for the Improved Integration of Health-Related Quality of Life Assessment in the Drug Regulatory ProcessDrug Information Journal, 2002
- Psychosocial Impact of Acne vulgarisDermatology, 2001
- Cross-cultural adaptation of health-related quality of life measures: Literature review and proposed guidelinesJournal of Clinical Epidemiology, 1993
- The MOS 36-Item Short-Form Health Survey (SF-36)Medical Care, 1993
- The MOS 36-ltem Short-Form Health Survey (SF-36)Medical Care, 1992