Amyloidosis With Plasma Cell Dyscrasia
- 1 April 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 34 (4), 209-214
- https://doi.org/10.1001/archneur.1977.00500160023003
Abstract
• In ten previously undiagnosed patients, we have found erstwhile-"primary" nonhereditary amyloidosis as an overlooked cause of a predominately sensory, painful, and hyperesthetic distal neuropathy occurring in middle-aged and older patients. These symptoms, associated with orthostatic hypotension, diarrhea or constipation, cardiac abnormality, and male impotence are virtually diagnostic (in the absence of diabetes mellitus). Tissue diagnosis is quickly made by crystal-violet metachromasia of amyloid in fresh-frozen sections of a muscle biopsy specimen. Immunoglobulin and bone marrow evidence of plasma cell dyscrasia in eight of the ten patients suggests that the neuropathy in this form of amyloidosis is actually secondary to a plasma-cell-originating dysproteinemia. Therapy with melphalan and prednisone was not of benefit.This publication has 12 references indexed in Scilit:
- Amyloid NeuropathyPublished by Qeios Ltd ,2020
- MYASTHENIA GRAVIS, CORTICOSTEROIDS, ANTICHOLINESTERASESAnnals of the New York Academy of Sciences, 1976
- THE RELATION OF THE PROPERTIES OF CONGO RED-STAINED AMYLOID FIBRILS TO THE β-CONFORMATIONJournal of Histochemistry & Cytochemistry, 1972
- Peripheral neuropathy and myelomaJournal of the Neurological Sciences, 1971
- Clinically significant cardiac amyloidosis: Clinicopathologic findings in 15 patientsThe American Journal of Cardiology, 1970
- Electron Microscopic Observations on a Fibrous Component in Amyloid of Diverse OriginsNature, 1959
- THE NEUROPATHY OF MULTIPLE MYELOMAJournal of Neurology, Neurosurgery & Psychiatry, 1958
- PRIMARY AMYLOIDOSIS PRESENTING WITH PERIPHERAL NEURITIS AND INTRACTABLE HEART-FAILUREThe Lancet, 1953
- AMYLOID NEURITISArchives of Neurology & Psychiatry, 1942
- A CASE OF PRIMARY GENERALIZED AMYLOID DISEASE WITH INVOLVEMENT OF THE NERVESBrain, 1938