Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery
- 1 July 2010
- journal article
- review article
- Published by Future Medicine Ltd in Nanomedicine
- Vol. 5 (5), 793-806
- https://doi.org/10.2217/nnm.10.50
Abstract
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in ‘smart’ – stimulus-responsive – peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.Keywords
This publication has 95 references indexed in Scilit:
- Release of Liposomal Contents by Cell-Secreted Matrix Metalloproteinase-9Bioconjugate Chemistry, 2009
- Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug DeliveryMolecular Pharmaceutics, 2009
- Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivoInternational Journal of Pharmaceutics, 2009
- Multi-Stimuli Sensitive Amphiphilic Block Copolymer AssembliesJournal of the American Chemical Society, 2009
- Tumor-Specific Anti-Nucleosome Antibody Improves Therapeutic Efficacy of Doxorubicin-Loaded Long-Circulating Liposomes against Primary and Metastatic Tumor in MiceMolecular Pharmaceutics, 2008
- Doxorubicin‐Loaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double‐Targeting Folate Receptor and Early Endosomal pHSmall, 2008
- Protease‐Triggered Unveiling of Bioactive NanoparticlesSmall, 2008
- Recent progress in tumor pH targeting nanotechnologyJournal of Controlled Release, 2008
- Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistanceJournal of Controlled Release, 2008
- Poly(ethylene glycol)–modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA deliveryNanomedicine: Nanotechnology, Biology and Medicine, 2007