SMART: a web-based tool for the study of genetically mobile domains
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- 1 January 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 28 (1), 231-234
- https://doi.org/10.1093/nar/28.1.231
Abstract
SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de). More than 400 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system, User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.Keywords
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