Isomaltose intolerance causing decreased ability to utilize dietary starch

Abstract

Oral tolerance tests were performed upon 4 children with intolerance to the ingestion of sucrose, and to a lesser extent, to starch. The test substance was a mixture of 1-6-α-oligosaccharides-containing isomaltose. The patients showed little elevation of blood glucose after the test dose and promptly developed diarrhea with large amounts of isomaltose in their stools. These results indicate that the condition is the result of deficiency of intestinal isomaltase and, probably, of invertase as well.