Morning administration of 0.4 U/kg/day insulin glargine 300 U/mL provides less fluctuating 24-hour pharmacodynamics and more even pharmacokinetic profiles compared with insulin degludec 100 U/mL in type 1 diabetes
Open Access
- 1 February 2018
- journal article
- research article
- Published by Elsevier BV in Diabetes & Metabolism
- Vol. 44 (1), 15-21
- https://doi.org/10.1016/j.diabet.2017.10.001
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- How to Assess the Quality of Glucose Clamps? Evaluation of Clamps Performed With ClampArt, a Novel Automated Clamp DeviceJournal of Diabetes Science and Technology, 2015
- Pharmacokinetics and Pharmacodynamics of Insulin Glargine Given in the Evening as Compared With in the Morning in Type 2 DiabetesDiabetes Care, 2014
- New Insulin Glargine 300 Units·mL−1 Provides a More Even Activity Profile and Prolonged Glycemic Control at Steady State Compared With Insulin Glargine 100 Units·mL−1Diabetes Care, 2014
- Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/mlDiabetes, Obesity and Metabolism, 2014
- Efficacy and Safety of Insulin Degludec in a Flexible Dosing Regimen vs Insulin Glargine in Patients With Type 1 Diabetes (BEGIN: Flex T1): A 26-Week Randomized, Treat-to-Target Trial With a 26-Week ExtensionJournal of Clinical Endocrinology & Metabolism, 2013
- Plasma Exposure to Insulin Glargine and Its Metabolites M1 and M2 After Subcutaneous Injection of Therapeutic and Supratherapeutic Doses of Glargine in Subjects With Type 1 DiabetesDiabetes Care, 2012
- Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre‐planned meta‐analysis of phase 3 trialsDiabetes, Obesity and Metabolism, 2012
- Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trialThe Lancet, 2012
- Fluctuation of Serum Basal Insulin Levels Following Single and Multiple Dosing of Insulin GlargineDiabetes Technology & Therapeutics, 2006
- Equipotency of insulin glargine and regular human insulin on glucose disposal in healthy subjects following intravenous infusionActa Diabetologica, 2003