Gymnastatins F−H, Cytostatic Metabolites from the Sponge-Derived Fungus Gymnascella dankaliensis
- 1 September 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 69 (10), 1384-1388
- https://doi.org/10.1021/np0600189
Abstract
Gymnastatins F -H (2-4) and gymnamide (5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H (4) was determined by its synthesis. Among these compounds, gymnastatins F (2) and G (3) possess a unique bicyclo[3.3.1]nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.Keywords
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