Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes
- 10 September 2002
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 59 (5), 746-748
- https://doi.org/10.1212/wnl.59.5.746
Abstract
The ε4 allele of the APOE gene increases the risk for AD, whereas the ε2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of ε4 had significantly more hippocampal and amygdalar atrophy than ε3ε3 subjects, but not more global brain atrophy. Carriers of ε2 did not have less brain atrophy than ε3ε3 subjects.This publication has 10 references indexed in Scilit:
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