Safety and Effect of Chlorhexidine Skin Cleansing on Skin Flora of Neonates in Bangladesh
- 1 June 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 26 (6), 492-495
- https://doi.org/10.1097/01.inf.0000261927.90189.88
Abstract
Chlorhexidine cleansing of newborn skin is a highly promising intervention for reducing neonatal mortality in developing countries, yet little is known of the mechanism of action. This study examined the impact of a single skin cleansing of hospitalized newborn infants in Bangladesh with baby wipes containing 0.25% chlorhexidine on both qualitative and quantitative skin flora. Within 72 hours of birth, the skin of newborns admitted to Dhaka Shishu Hospital was wiped with baby wipes containing 0.25% chlorhexidine (n = 67) or placebo (n = 66) solution. Skin condition was assessed and skin swabs were taken from 3 sites (axillary, peri-umbilical, inguinal) at baseline and 2 hours, 24 hours, 3 days and 7 days after treatment. Skin flora was quantified and colonizing species were identified. Skin cleansing with chlorhexidine had no adverse effects on skin condition, and resulted in minimal reduction (mean 0.5 degrees C) in body temperature. Positive skin culture rates 2 hours after skin cleansing were approximately 35%-55% lower than the baseline rates for placebo and chlorhexidine groups at all 3 sites. For the chlorhexidine group, positive skin culture rates remained significantly lower than the baseline rates for 24 hours to 3 days, whereas for the placebo group, beyond the first 2-hour follow-up, these values were not lower than baseline in any of the 3 sites. Chlorhexidine skin treatment produced more extended skin cleansing effects than the placebo treatment. It is possible that the quantitative and qualitative reductions observed in the skin flora might contribute to reducing neonatal infections.Keywords
This publication has 16 references indexed in Scilit:
- Impact of Newborn Skin-Cleansing With Chlorhexidine on Neonatal Mortality in Southern Nepal: A Community-Based, Cluster-Randomized TrialPublished by American Academy of Pediatrics (AAP) ,2007
- Safety and Impact of Chlorhexidine Antisepsis Interventions for Improving Neonatal Health in Developing CountriesThe Pediatric Infectious Disease Journal, 2006
- Effect of Predelivery Vaginal Antisepsis on Maternal and Neonatal Morbidity and Mortality in EgyptJournal of Women's Health, 2005
- Role of antimicrobial applications to the umbilical cord in neonates to prevent bacterial colonization and infection: a review of the evidenceThe Pediatric Infectious Disease Journal, 2003
- Effect of cleansing the birth canal with antiseptic solution on maternal and newborn morbidity and mortality in malawi: clinical trialBMJ, 1997
- Skin disinfection in preterm infants.Archives of Disease in Childhood, 1993
- What cord care--if any?Archives of Disease in Childhood, 1993
- Disinfection of the Skin with Detergent Preparations of Irgasan DP 300 and Other AntisepticsBMJ, 1974
- Preoperative Disinfection of Surgeons' Hands: Use of Alcoholic Solutions and Effects of Gloves on Skin FloraBMJ, 1974
- Clinical assessment of gestational age in the newborn infantThe Journal of Pediatrics, 1970