Hepatoprotective effect of Premna corymbosa (Burm. f.) Rottl. & Willd. leaves extract on CCl4 induced hepatic damage in Wistar albino rats

Abstract

To investigate the hepetoprotective activity of Premna corymbosa leaves against carbon tetrachloride (CCl₄) induced hepatic damage. Hepatotoxicity was induced in wistar rats of both sexes by intraperitoneal injection of CCl₄, 1 mL/kg body weight for every 72 h. The ethanolic extract of Premna corymbosa leaves were administrated at doses of 200 & 400 mL/kg body weight, p. o., daily for 14 days. The hepatotoxicity and its prevention was assessed by serum markers like serum alkaline phosphatase (SALP), serum triglycerides (STG), serum total protein (STP), serum cholesterol (SC), and liver wet weight and histopathological studies of the liver. In treatment with the ethanolic extract, the toxic effect of CCl₄ was controlled significantly (P < 0.01) by restoration of the levels of biochemical parameters as compared to normal and standard drug silymarin treated groups. The liver weight was reduced by the ethanolic extract treated groups. The histopathology of the liver sections evidenced the hepatoprotective activity. The ethanolic extract of the leaves of Premna corymbosa possess significant acute hepatoprotective activity. Premna corymbosa can be recommended for the liver disorders.