Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus
Open Access
- 1 January 2010
- journal article
- research article
- Published by Medknow in Indian Journal of Pharmacology
- Vol. 42 (5), 283-8
- https://doi.org/10.4103/0253-7613.70108
Abstract
Objective : The aim of this study was to study the ameliorative effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression. Materials and Methods : The study was carried out using male albino rats (200 ± 50 g). The effect of O. sanctum and C. sinensis was evaluated for anxiety and depression using elevated plus maze (EPM) test, open field test (OFT), forced swim test (FST), and tail suspension test (TST). Result : Restraint stress (3 h/day for six consecutive days) induced a significant reduction in both the percentage number of entries and time spent in open arms in EPM, and these changes were reversed with post-treatment of aqueous extract of O. sanctum and C. sinensis (100 mg/kg for 6 days). Restraint stress-induced (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum and C. sinensis in OFT. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST. Conclusion : O. sanctum and C. sinensis possess anxiolytic and antidepressant activities.Keywords
This publication has 23 references indexed in Scilit:
- Possible involvement of free radicals in the differential neurobehavioral responses to stress in male and female ratsBehavioural Brain Research, 2007
- A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-mazeEuropean Journal of Pharmacology, 2003
- Stress, Metaplasticity, and AntidepressantsCurrent Molecular Medicine, 2002
- Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.Biological & Pharmaceutical Bulletin, 2001
- Harmless Herbs? A Review of the Recent LiteratureThe American Journal of Medicine, 1998
- Effect of Theanine, r-Glutamylethylamide, on Brain Monoamines and Striatal Dopamine Release in Conscious RatsNeurochemical Research, 1998
- Structure-antioxidant activity relationships of flavonoids and phenolic acidsFree Radical Biology & Medicine, 1996
- The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.1992
- The tail suspension test: A new method for screening antidepressants in micePsychopharmacology, 1985
- The relation between fear induced by novel stimulation and exploratory drive.Journal of Comparative and Physiological Psychology, 1955