The Landmark JDRF Continuous Glucose Monitoring Randomized Trials: a Look Back at the Accumulated Evidence
- 27 April 2012
- journal article
- Published by Springer Science and Business Media LLC in Journal of Cardiovascular Translational Research
- Vol. 5 (4), 380-387
- https://doi.org/10.1007/s12265-012-9364-9
Abstract
Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 %. The secondary study evaluated 129 patients with A1c 25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.Keywords
This publication has 22 references indexed in Scilit:
- Factors Predictive of Severe Hypoglycemia in Type 1 DiabetesDiabetes Care, 2011
- Quality-of-Life Measures in Children and Adults With Type 1 DiabetesDiabetes Care, 2010
- The Cost-Effectiveness of Continuous Glucose Monitoring in Type 1 DiabetesDiabetes Care, 2010
- Effectiveness of Continuous Glucose Monitoring in a Clinical Care EnvironmentDiabetes Care, 2009
- Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 DiabetesDiabetes Care, 2009
- Sustained Benefit of Continuous Glucose Monitoring on A1C, Glucose Profiles, and Hypoglycemia in Adults With Type 1 DiabetesDiabetes Care, 2009
- The Effect of Continuous Glucose Monitoring in Well-Controlled Type 1 DiabetesDiabetes Care, 2009
- Continuous Glucose Monitoring and Intensive Treatment of Type 1 DiabetesNew England Journal of Medicine, 2008
- Adverse Events and Their Association With Treatment Regimens in the Diabetes Control and Complications TrialDiabetes Care, 1995
- Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications TrialThe Journal of Pediatrics, 1994