Regulatory T cells and tumour immunity – observations in mice and men
- 7 December 2007
- journal article
- review article
- Published by Wiley in Immunology
- Vol. 123 (2), 157-163
- https://doi.org/10.1111/j.1365-2567.2007.02748.x
Abstract
An enormous body of work supports a role for CD4+ CD25+ regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.Keywords
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