Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain
- 29 August 2009
- journal article
- Published by Springer Science and Business Media LLC in Genes & Nutrition
- Vol. 4 (4), 309-314
- https://doi.org/10.1007/s12263-009-0141-6
Abstract
The cholinergic theory of aging states that dysfunction of cholinergic neurons arising from the basal forebrain and terminating in the cortex and hippocampus may be involved in the cognitive decline that occurs during aging and Alzheimer’s disease. Despite years of research, pharmacological interventions to treat or forestall the development of Alzheimer’s disease have primarily focused on enhancing cholinergic transmission, either through increasing acetylcholine (ACh) synthesis or inhibition of the acetylcholinesterase enzyme responsible for ACh hydrolysis. However, recent studies have indicated that dietary supplementation can impact the cholinergic system, particularly during aging. The purpose of the present review is to examine the relevant research suggesting that cholinergic functioning may be maintained during aging via consuming a diet containing polyunsaturated fatty acids (PUFAs). The data reviewed herein indicate that, at least in animal studies, inclusion of PUFAs in the diet can improve cholinergic transmission in the brain, possibly leading to improvements in cognitive functioning.Keywords
This publication has 51 references indexed in Scilit:
- Dose-dependent effects of walnuts on motor and cognitive function in aged ratsBritish Journal of Nutrition, 2008
- Whole body distribution of deuterated linoleic and α-linolenic acids and their metabolites in the ratJournal of Lipid Research, 2007
- Fatty acid composition of nuts – implications for cardiovascular healthBritish Journal of Nutrition, 2006
- The significance of the cholinergic system in the brain during aging and in Alzheimer’s diseaseJournal of Neural Transmission, 2006
- A high n-6 polyunsaturated fatty acid diet reduces muscarinic M2/M4 receptor binding in the rat brainJournal of Chemical Neuroanatomy, 2005
- Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane orderLife Sciences, 2004
- Effect of Dietary Docosahexaenoic Acid and Catechins on Maze Behavior in MiceAnnals of Nutrition and Metabolism, 2004
- Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegansJournal of Cell Science, 2003
- Effect of a High .ALPHA.-Linolenate and High Linoleate Diet on Membrane-Associated Enzyme Activities in Rat Brain - Modulation of Na+,K+-ATPase Activity at Suboptimal Concentrations of ATP.Biological & Pharmaceutical Bulletin, 1995
- Membrane lipid fatty acids and regulation of membrane-bound enzymes. Allosteric behaviour of erythrocyte Mg2+-ATPase, (Na+ + K2+)-ATPase and acetylcholineasterase from rats fed different fat-supplemented dietsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973