Low-level laser therapy (670 nm) on viability of random skin flap in rats
- 20 March 2008
- journal article
- Published by Springer Science and Business Media LLC in Lasers in Medical Science
- Vol. 24 (2), 209-213
- https://doi.org/10.1007/s10103-008-0551-5
Abstract
This study investigated the effects of 670 nm laser, at different fluences, on the viability of skin flap in rats. One hundred male animals were used. The animals were divided into control group; group treated with 3 J/cm2; group treated with 6 J/cm2; group treated with 12 J/cm2 and group treated with 24 J/cm2. The skin flap was made on the backs of all animals studied, with a plastic sheet interposed between the flap and the donor site. Laser irradiation was done immediately after the surgery and on days 1, 2, 3 and 4 after surgery. The percentage of necrosis of the flap was calculated at the 7th postoperative day. Additionally, a sample of each flap was collected to enable us to count the blood vessels. Treated animals showed a statistically significant smaller area of necrosis than did the control group. The necrosis in the treated groups was 41.82% (group 2), 36.51% (group 3), 29.45% (group 4) and 20.37% (group 5). We also demonstrated that laser irradiation at 670 nm, at all doses used, had a stimulatory effect on angiogenesis. Our study showed that the 670 nm laser was efficient to increase the viability of the skin flap, at all fluences used, with a tendency of reaching better results at higher doses.Keywords
This publication has 25 references indexed in Scilit:
- Helium-neon laser in viability of random skin flap in ratsLasers in Surgery and Medicine, 2005
- Comparison of the photostimulatory effects of visible He‐Ne and infrared Ga‐As lasers on healing impaired diabetic rat woundsLasers in Surgery and Medicine, 2003
- Effects of Diode Laser Therapy on Blood Flow in Axial Pattern Flaps in the Rat ModelLasers in Medical Science, 2002
- Biostimulation of bone marrow cells with a diode soft laserClinical Oral Implants Research, 2000
- Mechanisms of low-power laser light action on cellular levelPublished by SPIE-Intl Soc Optical Eng ,2000
- Low intensity laser therapy: Still not an established clinical toolLasers in Surgery and Medicine, 1995
- The Efficacy of Laser Therapy for Musculoskeletal and Skin Disorders: A Criteria-Based Meta-analysis of Randomized Clinical TrialsPTJ: Physical Therapy & Rehabilitation Journal, 1992
- The Effect of Low-Energy Laser on Skin-Flap Survival in the Rat and Porcine Animal ModelsPlastic and Reconstructive Surgery, 1992
- The biomedical effects of laser applicationLasers in Surgery and Medicine, 1985
- Skin Flap FailurePlastic and Reconstructive Surgery, 1983