ENDOPLASMIC RETICULUM–ASSOCIATED DEGRADATION
- 1 November 2005
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 21 (1), 435-456
- https://doi.org/10.1146/annurev.cellbio.21.012704.133250
Abstract
Secretory and transmembrane proteins enter the secretory pathway through the protein-conducting Sec61 channel in the membrane of the endoplasmic reticulum. In the endoplasmic reticulum, proteins fold, are frequently covalently modified, and oligomerize before they are packaged into transport vesicles that shuttle them to the Golgi complex. Proteins that misfold in the endoplasmic reticulum are selectively transported back across the endoplasmic reticulum membrane to the cytosol for degradation by proteasomes. Depending on the topology of the defect in the protein, cytosolic or lumenal chaperones are involved in its targeting to degradation. The export channel for misfolded proteins is likely also formed by Sec61p. Export may be powered by AAA-ATPases of the proteasome 19S regulatory particle or Cdc48p/p97. Exported proteins are frequently ubiquitylated prior to degradation and are escorted to the proteasome by polyubiquitin-binding proteins.Keywords
This publication has 97 references indexed in Scilit:
- The protein translocation channel binds proteasomes to the endoplasmic reticulum membraneThe EMBO Journal, 2005
- Cystic Fibrosis Transmembrane Conductance Regulator Degradation Depends on the Lectins Htm1p/EDEM and the Cdc48 Protein Complex in YeastMolecular Biology of the Cell, 2004
- The ΔF508 Mutation Disrupts Packing of the Transmembrane Segments of the Cystic Fibrosis Transmembrane Conductance RegulatorPublished by Elsevier BV ,2004
- A Striking Quality Control Subcompartment inSaccharomyces cerevisiae: The Endoplasmic Reticulum-associated CompartmentMolecular Biology of the Cell, 2004
- Yeast N‐glycanase distinguishes between native and non‐native glycoproteinsEMBO Reports, 2004
- Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosolThe Journal of cell biology, 2003
- Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulatorThe Journal of cell biology, 2003
- Regulation of Hmg-Coa Reductase Degradation Requires the P-Type Atpase Cod1p/Spf1pThe Journal of cell biology, 2000
- Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox PotentialThe Journal of cell biology, 1998
- Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleus.The Journal of cell biology, 1988