Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut
- 1 April 1992
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 1 (1), 50-55
- https://doi.org/10.1038/ng0492-50
Abstract
Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.Keywords
This publication has 33 references indexed in Scilit:
- Basic Local Alignment Search ToolJournal of Molecular Biology, 1990
- Basic local alignment search toolJournal of Molecular Biology, 1990
- The structure and function of the homeodomainBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1989
- DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9Cell, 1989
- Structure of pre-pro-von Willebrand factor and its expression in heterologous cellsNature, 1986
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesCell, 1986
- Molecular organization of the cut locus of drosophila melanogasterCell, 1985
- Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal LocalizationScience, 1985
- The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expressionCell, 1982
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970