Sequential Effects of Increasing Propofol Sedation on Frontal and Temporal Cortices as Indexed by Auditory Event-related Potentials
- 1 March 2004
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 100 (3), 617-625
- https://doi.org/10.1097/00000542-200403000-00023
Abstract
Background It is an open question whether cognitive processes of auditory perception that are mediated by functionally different cortices exhibit the same sensitivity to sedation. The auditory event-related potentials P1, mismatch negativity (MMN), and early right anterior negativity (ERAN) originate from different cortical areas and reflect different stages of auditory processing. The P1 originates mainly from the primary auditory cortex. The MMN is generated in or in the close vicinity of the primary auditory cortex but is also dependent on frontal sources. The ERAN mainly originates from frontal generators. The purpose of the study was to investigate the effects of increasing propofol sedation on different stages of auditory processing as reflected in P1, MMN, and ERAN. Methods The P1, the MMN, and the ERAN were recorded preoperatively in 18 patients during four levels of anesthesia adjusted with target-controlled infusion: awake state (target concentration of propofol 0.0 microg/ml), light sedation (0.5 microg/ml), deep sedation (1.5 microg/ml), and unconsciousness (2.5-3.0 microg/ml). Simultaneously, propofol anesthesia was assessed using the Bispectral Index. Results Propofol sedation resulted in a progressive decrease in amplitudes and an increase of latencies with a similar pattern for MMN and ERAN. MMN and ERAN were elicited during sedation but were abolished during unconsciousness. In contrast, the amplitude of the P1 was unchanged by sedation but markedly decreased during unconsciousness. Conclusion The results indicate differential effects of propofol sedation on cognitive functions that involve mainly the auditory cortices and cognitive functions that involve the frontal cortices.Keywords
This publication has 37 references indexed in Scilit:
- A Neuroanatomical Construct for the Amnesic Effects of PropofolAnesthesiology, 2002
- Music matters: Preattentive musicality of the human brainPsychophysiology, 2002
- Subanesthetic Isoflurane Affects Task-induced Brain Activation in a Highly Specific MannerAnesthesiology, 2001
- Differentiating ERAN and MMN: An ERP studyNeuroReport, 2001
- Propofol Anesthesia and Cerebral Blood Flow Changes Elicited by Vibrotactile Stimulation: A Positron Emission Tomography StudyJournal of Neurophysiology, 2001
- Brain Mechanisms of Propofol-Induced Loss of Consciousness in Humans: a Positron Emission Tomographic StudyJournal of Neuroscience, 1999
- Measurement and interpretation of the mismatch negativityBehavior Research Methods, Instruments & Computers, 1998
- Evoked potentials recorded from the auditory cortex in man: evaluation and topography of the middle latency componentsElectroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1994
- Brain Generators Implicated in the Processing of Auditory Stimulus Deviance: A Topographic Event‐Related Potential StudyPsychophysiology, 1990
- Midlatency auditory evoked responses: Differential effects of sleep in the humanElectroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1986