Tuned for Transposition: Molecular Determinants Underlying the Hyperactivity of a Stowaway MITE
- 11 September 2009
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5946), 1391-1394
- https://doi.org/10.1126/science.1175688
Abstract
MITE-y Jumps: Tranposable elements are genetic elements ubiquitous to most genomes, and their expansion, loss, and potential movement are major components of genome evolution. A type of noncoding transposable element in plants, known as a MITE (minature inverted repeat transposable element), shows evidence of recent expansion within specific rice genomes. However, these elements lack the necessary transposase to help them move. Yang et al. (p. 1391 ; see the Perspective by González and Petrov ) found that the expansion of MITEs occurs because they exploit the activity of other, unrelated, transposons and consequently identified the molecular determinants that allowed mobilization. Surprisingly, the element coding for the transposase repressed its own movement unless the MITE was present. These findings may explain why some genetic elements can replicate within the genome and reach high copy numbers while others do not.This publication has 18 references indexed in Scilit:
- A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable ElementsPLOS ONE, 2007
- Mobilization and evolutionary history of miniature inverted-repeat transposable elements (MITEs) in Beta vulgaris L.Chromosome Research, 2006
- Dramatic amplification of a rice transposable element during recent domesticationProceedings of the National Academy of Sciences of the United States of America, 2006
- A Rice Tc1/Mariner-Like Element Transposes in YeastTHE PLANT CELL ONLINE, 2006
- A Two-Edged Role for the Transposable ElementKiddoin therice ubiquitin2PromoterTHE PLANT CELL ONLINE, 2005
- Assembly of the mariner Mos1 Synaptic ComplexMolecular and Cellular Biology, 2005
- Using rice to understand the origin and amplification of miniature inverted repeat transposable elements (MITEs)Current Opinion in Plant Biology, 2004
- The plant MITE mPing is mobilized in anther cultureNature, 2003
- Mariner -like transposases are widespread and diverse in flowering plantsProceedings of the National Academy of Sciences of the United States of America, 2001
- LTR-retrotransposons and MITEs: important players in the evolution of plant genomesCurrent Opinion in Genetics & Development, 1995