Glypican‐3 expression is correlated with poor prognosis in hepatocellular carcinoma
Open Access
- 10 July 2009
- journal article
- Published by Wiley in Cancer Science
- Vol. 100 (8), 1403-1407
- https://doi.org/10.1111/j.1349-7006.2009.01206.x
Abstract
The relationship between overexpression of glypican (GPC)-3 that is specific for hepatocellular carcinoma (HCC) and the prognosis has not yet been clarified. We attempted to determine the expression profile of GPC3 in association with the clinicopathological factors by immunohistochemical analysis in HCC patients and investigated the potential prognostic value of GPC3 by comparing the survival rate between the GPC3-positive and GPC3-negative HCC patients. Primary HCC tissue samples (n = 107) obtained from patients who had undergone hepatectomy between 2000 and 2001 were analyzed. GPC3 expression was less frequently observed in well-differentiated HCC than in moderately and poorly differentiated HCC, the difference in the frequency being statistically significant. GPC3-positive HCC patients had a significantly lower 5-year survival rate than the GPC3-negative HCC patients (54.5 vs 87.7%, P = 0.031). Among 80 of the 107 (74.6%) patients with initial treatment who underwent hepatectomy, none of GPC3-negative HCC patients (n = 16, 20.0%) died during the follow-up period. No deaths were noted in the GPC3-negative HCC patients among the 71 (88.7%) patients with moderately and poorly differentiated HCC. Multivariate analysis identified GPC3 expression (P = 0.034) as an independent prognostic factor for the overall survival. We showed that GPC3 expression is correlated with a poor prognosis in HCC patients. (Cancer Sci 2009)Keywords
This publication has 26 references indexed in Scilit:
- Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β‐catenin/TCFCancer Science, 2008
- RETRACTED ARTICLE: Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulationBreast Cancer Research and Treatment, 2008
- GlypicansGenome Biology, 2008
- Prognostic molecular markers in hepatocellular carcinoma: A systematic reviewEuropean Journal of Cancer, 2007
- Identification of HLA-A2- or HLA-A24-Restricted CTL Epitopes Possibly Useful for Glypican-3-Specific Immunotherapy of Hepatocellular CarcinomaClinical Cancer Research, 2006
- Early and Late Recurrence After Liver Resection for Hepatocellular CarcinomaAnnals of Surgery, 2006
- The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinomaLaboratory Investigation, 2005
- Highly Sensitive Detection of Melanoma at an Early Stage Based on the Increased Serum Secreted Protein Acidic and Rich in Cysteine and Glypican-3 LevelsClinical Cancer Research, 2005
- Identification of Glypican-3 as a Novel Tumor Marker for MelanomaClinical Cancer Research, 2004
- Recurrence of hepatocellular carcinoma after surgeryBritish Journal of Surgery, 1996