Standard 6: Age Groups for Pediatric Trials
Open Access
- 1 June 2012
- journal article
- review article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 129 (Supplement), S153-S160
- https://doi.org/10.1542/peds.2012-0055i
Abstract
A recent study highlighted variable treatment efficacy in children versus adults. In this study, 128 meta-analyses from Cochrane reviews, containing data on at least 1 adult and 1 pediatric randomized controlled trial (RCT) with a binary primary efficacy outcome, were reviewed.1 The authors found that in all except 1 case, the 95% confidence intervals could not exclude a relative difference in treatment efficacy between adults and children of >20%; in two-thirds of these cases, the relative difference in observed point estimates was >50%. The study also highlighted the paucity of RCTs in pediatrics; the median number of children per meta-analysis was 2.5 times smaller than the number of adults.Keywords
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