Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
- 20 February 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5661), 1179-1181
- https://doi.org/10.1126/science.1092089
Abstract
PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine 383 . The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.Keywords
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