Oil Machinery Fluid of Craniopharyngioma. Biochemical Analysis: Clinico-Pathological Correlation

Abstract

Craniopharyngiomas are histologically benign tumors, but they have a tendency to become adherent around the pituitary gland and pituitary stalk, including the optic nerves, optic chiasm, intracranial arteries and the brain itself. 15 cases of craniopharyngiomas were included in this study. The oil fluid biochemical analysis was made; glucose, cholesterol, lipids, proteins, lactate dehydrogenase, globulins, calcium, sodium, etc. and Western Blot was performed for 2 and 9 metalloproteins. Clinicopatological correlation was made. Groups were divided in recurrent and non-recurrent tumor. The age of patient ranged from 18 to 51 yr 11 (mean of 30yrs). 11 (73%) were females and 4 (27%) were male. Recurrence was in 8 (53%) cases. We analyze the mean of laboratory results obtaining normal to low serum values for ions and high fluid values for all the elements studied. There was no statically significance between them, but we observe the patients which had a big tumor, recurrence and green color oil fluid presented high levels of these components. By the other hand, little not recurrent tumors and with a yellow oil fluid aspect, had low serum values of alkaline phosphatase, serum glutamic oxaloacetic and glutamic-pyruvic transaminases. The output of these components in the Central Nervous System can be toxic and produce more inflammatory response.