The Matrix Revolution: Matricellular Proteins and Restructuring of the Cancer Microenvironment
- 1 July 2020
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 80 (13), 2705-2717
- https://doi.org/10.1158/0008-5472.can-18-2098
Abstract
The extracellular matrix (ECM) surrounding cells is indispensable for regulating their behavior. The dynamics of ECM signaling are tightly controlled throughout growth and development. During tissue remodeling, matricellular proteins (MCPs) are secreted into the ECM. These factors do not serve classical structural roles, but rather regulate matrix proteins and cell-matrix interactions to influence normal cellular functions. In the tumor microenvironment, it is becoming increasingly clear that aberrantly expressed MCPs can support multiple hallmarks of carcinogenesis by interacting with various cellular components that are coupled to an array of downstream signals. Moreover, MCPs also reorganize the biomechanical properties of the ECM to accommodate metastasis and tumor colonization. This realization is stimulating new research on MCPs as reliable and accessible biomarkers in cancer, as well as effective and selective therapeutic targets.Funding Information
- Cancer Research Society and the Kidney Cancer Research Network of Canada
- Cancer Research Society
- Kidney Cancer Research Network of Canada
- Hôpital Maisonneuve-Rosemont Foundation
- KRESCENT (KRES180003)
- Kidney Foundation of Canada
- Canadian Society of Nephrology
- Canadian Institutes of Health Research
- Cole Foundation Early Career Transition Award
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